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. 2020 Sep 23;11:573823. doi: 10.3389/fimmu.2020.573823

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Copyright © 2020 Wei, Wang, Kuang, Wu, Zhao, Zhang, Li, Zheng, Zhang, Long, Guo, Nie, Yang and Tong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Production of ICAM1-specific CAR-T Cells. (A) Schematic representation of the ICAM1-specific CAR and control CAR (anti-CD19 CAR) constructs containing the following fragments: mG2-scFv/anti-CD19-scFv; CD8α transmembrane domain; intracellular signaling domains of CD28, 4-1BB, and CD3-ζ. (B) The ICAM1-CAR and CD19-CAR expressing human T cells were stained with antigen and then detected by FACS. (C) Ten days after lentivirus CAR transduction, the subsets and phenotypes of NT and ICAM1-specific CAR-T cells were analyzed by FACS, including the expression of CD4, CD8, CD45RO, and CD62L.