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. 2020 Sep 23;11:573823. doi: 10.3389/fimmu.2020.573823

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Copyright © 2020 Wei, Wang, Kuang, Wu, Zhao, Zhang, Li, Zheng, Zhang, Long, Guo, Nie, Yang and Tong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Antitumor effect of ICAM1-specific CAR-T cells in xenograft models. (A) Treatment scheme used in the MDA-MB-231-luc and SKBR3-luc xenograft models. (B,C) An image of the MDA-MB-231-luc and SKBR3-luc allograft tumor, respectively, in mice (five mice per group). (D) Tumor total flux data (in p/s) were calculated using Living Image software. Tumor growth rates are shown as mean values (unpaired two-tailed Student’s t-tests, **p < 0.01). (E,F) Fluorescence intensity changes of MDA-MB-231-luc and SKBR3-luc heterologous tumors in mice. (G) Body weight measurements during the treatment. (H) Overall survival of mice in each group.