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Efficacy of ICAM1-specific CAR-T cells therapy and cytokine release in vivo. (A–D) The concentrations of IFN-γ, IL-2, TNF-α, and IL-6 in the peripheral blood of mice, which was collected at 24 h after injection of T cells, were measured by ELISA. Each experiment was repeated at least three times. For statistical analysis, unpaired two-tailed Student’s t-tests were applied. ***p < 0.001.
