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Diagnostic criteria of acute-on-chronic liver failure and their grades. Adapted from Moreau R, Jalan R, Gines P et al. Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis. Gastroenterology 2013;144:1426–37. ACLF = acute-on-chronic liver failure; BD = brain dysfunction; KD = kidney dysfunction; KF = kidney failure; OF = organ failure.
