Table 1.

Variations in worldwide definitions of acute-on-chronic liver failure

Consortium	EASL-CLIF1	APASL2	NACSELD3
Diagnostic parameters	Specified criteria using CLIF-OF score(s) for OF, 28-day mortality rate >15% from AD of cirrhosis, with/without prior decompensation often caused by infection	Acute jaundice and coagulopathy, followed by ascites ±HE <4 weeks in undiagnosed or diagnosed chronic liver disease, including cirrhosis	Specified criteria for ≥2 OFs in patients with infection, at or during admission
Exclusion criteria	Patients admitted electively for procedures or therapy, or those with hepatocellular carcinoma outside Milan criteria, or receiving immunosuppressive therapy, with HIV or with severe chronic extrahepatic disease	Bacterial infection or previous AD	Outpatients with infection, any patient with HIV infection, prior organ transplants or disseminated malignancies

AD = acute decompensation; ACLF = acute-on-chronic liver failure; APASL = Asian Pacific Association for the Study of the Liver; CLIF-OF = Chronic Liver Failure – Organ Failure; EASL-CLIF = European Association for the Study of the Liver – Chronic Liver Failure; HE = hepatic encephalopathy; NACSELD = North American Consortium for the Study of End-stage Liver Disease.