Table 1.

Options for the medical management of cholestatic pruritis

Pharmacotherapy	Dose	Notes
Cholestyramine	4 g/day to a maximum of 16 g/day as required	Administration requires adequate spacing to avoid affecting the absorption of other medications
Rifampicin	300–600 mg/day	Needs careful monitoring of LFTs; small risk of hepatotoxicity
Naltrexone	50 mg/day	Careful dosing required to avoid opioid withdrawal side effects
Sertraline	100 mg/day
Gabapentin	300 mg/day, dose titrate as normal

LFTs = liver function tests.