Table 1.

Pupillometry measurements in the different patient groups

Variable	Sedated (Ramsay score 6)		Awake (Ramsay score 2)
	Group a: COVID-19 negative (n = 14)	Group b: COVID-19 positive (+) (n = 6)	Group c: COVID-19 negative (n = 9)	Group d: COVID-19 positive (n = 12)
NPi	4.52 (3.98–4.70)	4.44 (4.18–4.61)	4.53 (4.45–4.55)	4.64 (4.39–4.71)
Size	2.26 (1.99–2.72)**	2.10 (2.05–2.63)†	3.69 (3.18–4.53)**	3.50 (3.06–4.20)†
Min	1.87 (1.66–2.32)*	1.82 (1.73–2.19)	2.60 (2.27–2.73)*	2.33 (2.05–2.80)
ΔSize (%)	15.7 (12.9–20.0)**	18.2 (15.6–20.1)††	30.7 (26.5–32.8)**	35.0 (30.4–37.3)††
CV	0.82 (0.76–1.05)**	0.96 (0.80–1.07)††	1 .95 (1.55–2.32)**	2.29 (1.93–2.54)††
MCV	1.36 (1.11–1.52)**	1.39 (1.31–1.59)††	2.98 (2.89–3.68)**	3.50 (3.27–4.08)††
DV	0.37 (0.29–0.45)**	0.43 (0.32–0.52)††	1.03 (0.84–1.17)**	1.03 (0.91–1.17)††
Latency	0.26 (0.24–0.28)	0.29 (0.25–0.30)	0.24 (0.23–0.25)	0.25 (0.23–0.26)

All values in table are presented as median with the interquartile range in parentheses

COVID-19 Coronavirus Disease-19, NPi neurological pupil index, Min minimum pupil size, ΔSize (%) (Size-Min)/Size × 100%, CV constriction velocity, MCV maximum constriction velocity, DV dilation velocity

*Significant difference at p < 0.05 (Mann–Whitney U test) between groups a and c; **significant difference at p < 0.001 (Mann–Whitney U test) between groups a and c; ^†significant difference at p < 0.05 (Mann–Whitney U test) between groups b and d; ^††significant difference at p < 0.001 (Mann–Whitney U test) between groups b and d