Table 3.

Mutation frequency (N=221) of different genes in breast cohort

Gene (s)	Tier I/II (N=77)	Tier III (N=144)	Total (N=221)
AKT1	3 (3.9%)	-	3 (1.36%)
APC	-	1 (0.69%)	1 (0.45%)
AR	-	4 (2.78%)	4 (1.81%)
ATM	-	4 (2.78%)	4 (1.81%)
ATR	-	4 (2.78%)	4 (1.81%)
BAP1	-	1 (0.69%)	1 (0.45%)
BMPR1A	-	1 (0.69%)	1 (0.45%)
BRCA1	-	2 (1.39%)	2 (0.9%)
BRCA2	-	4 (2.78%)	4 (1.81%)
BRIP1	1 (1.3%)	1 (0.69%)	2 (0.9%)
CASP8	-	3 (2.08%)	3 (1.36%)
CBFB	3 (3.9%)	2 (1.39%)	5 (2.26%)
CCND1	-	1 (0.69%)	1 (0.45%)
CDH1	2 (2.6%)	6 (4.17%)	8 (3.62%)
CSMD1	1 (1.3%)	5 (3.47%)	6 (2.71%)
EGFR	-	2 (1.39%)	2 (0.9%)
EP300	-	2 (1.39%)	2 (0.9%)
EPCAM	-	2 (1.39%)	2 (0.9%)
ERBB2	-	2 (1.39%)	2 (0.9%)
ERBB3	-	5 (3.47%)	5 (2.26%)
ESR1	-	2 (1.39%)	2 (0.9%)
EXOC2	-	2 (1.39%)	2 (0.9%)
EXT2	-	1 (0.69%)	1 (0.45%)
FGFR1	-	1 (0.69%)	1 (0.45%)
FGFR2	-	1 (0.69%)	1 (0.45%)
GATA3	11 (14.29%)	-	11 (4.98%)
GEN1	1 (1.3%)	1 (0.69%)	2 (0.9%)
HERC1	-	3 (2.08%)	3 (1.36%)
MAP2K4	2 (2.6%)	1 (0.69%)	3 (1.36%)
MAP3K1	11 (14.29%)	4 (2.78%)	15 (6.79%)
MED12	-	1 (0.69%)	1 (0.45%)
MEN1	-	2 (1.39%)	2 (0.9%)
MLH1	-	2 (1.39%)	2 (0.9%)
MSH2	-	5 (3.47%)	5 (2.26%)
MSH6	1 (1.3%)	-	1 (0.45%)
MUTYH	-	1 (0.69%)	1 (0.45%)
NBN	-	4 (2.78%)	4 (1.81%)
NCOR1	-	1 (0.69%)	1 (0.45%)
NEK2	1 (1.3%)	1 (0.69%)	2 (0.9%)
NF1	-	2 (1.39%)	2 (0.9%)
PALB2	1 (1.3%)	1 (0.69%)	2 (0.9%)
PALLD	-	2 (1.39%)	2 (0.9%)
PBRM1	-	1 (0.69%)	1 (0.45%)
PIK3CA	22 (28.57%)	10 (6.94%)	32 (14.48%)
PIK3R1	-	1 (0.69%)	1 (0.45%)
PMS2	-	1 (0.69%)	1 (0.45%)
PTEN	4 (5.19%)	3 (2.08%)	7 (3.17%)
RAD51	-	1 (0.69%)	1 (0.45%)
RAD51C	-	1 (0.69%)	1 (0.45%)
RAD51D	-	1 (0.69%)	1 (0.45%)
RET	-	3 (2.08%)	3 (1.36%)
SEPT9	-	2 (1.39%)	2 (0.9%)
SMARCA4	-	2 (1.39%)	2 (0.9%)
SYNE1	-	6 (4.17%)	6 (2.71%)
TP53	13 (16.88%)	16 (11.11%)	29 (13.12%)
TRAF5	-	1 (0.69%)	1 (0.45%)
WEE1	-	3 (2.08%)	3 (1.36%)
ZBED4	-	2 (1.39%)	2 (0.9%)