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Mutation spectrum of breast and ovarian tumors
| Breast (N=108) | Ovarian (N=14) | |||||
|---|---|---|---|---|---|---|
|
|
|
|||||
| Tier I/II | Tier III | Total | Tier I/II | Tier III | Total | |
| APC | 1 | 1 | ||||
| AR | 4 | 4 | ||||
| ATM | 4 | 4 | 1 | 1 | ||
| ATR | 4 | 4 | 1 | 1 | ||
| BRCA1 | 2 | 2 | 1 | 1 | 2 | |
| BRCA2 | 4 | 4 | ||||
| BRIP1 | 1 | 1 | 2 | |||
| CBFB | 3 | 2 | 5 | |||
| CDH1 | 2 | 6 | 8 | |||
| CSMD1 | 1 | 5 | 6 | |||
| ERBB3 | 5 | 5 | 1 | 1 | ||
| EXOC2 | 2 | 2 | 1 | 1 | ||
| EXT2 | 1 | 1 | ||||
| GATA3 | 11 | 11 | ||||
| HERC1 | 3 | 3 | 1 | 1 | ||
| KRAS | 4 | 4 | ||||
| MAP2K4 | 2 | 1 | 3 | 1 | 1 | |
| MAP3K1 | 11 | 4 | 15 | 2 | 2 | |
| MSH2 | 5 | 5 | ||||
| NBN | 4 | 4 | ||||
| NF1 | 2 | 2 | 1 | 1 | ||
| PALB2 | 1 | 1 | 2 | 2 | 2 | |
| PIK3CA | 22 | 10 | 32 | 2 | 2 | |
| PTEN | 4 | 3 | 7 | 1 | 1 | |
| RAD51C | 1 | 1 | ||||
| RB1 | 1 | 1 | ||||
| SYNE1 | 6 | 6 | ||||
| TP53 | 13 | 16 | 29 | 9 | 2 | 11 |
