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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: FASEB J. 2019 Nov 29;34(1):1247–1269. doi: 10.1096/fj.201902163R

Figure 7: Effect of isoform-selective inhibitors of GSK3α or GSK3β on its in vitro fertilization ability.

Figure 7:

A) Chemical structure of GSK3α inhibitor, BRD0705 and GSK3β inhibitor, BRD3731 (43). B) Spermatozoa were incubated with BRD0705 (20μM) and BRD3731 (10μM) under capacitating condition for 90 min and used for IVF; BRD0705 significantly inhibited the fertilization of eggs whereas the GSK3β inhibitor BRD3731 had no effect compared to control. C) Representative bright-field pictures of two-cell embryo formation corresponding to the treatments described above.