Table 2: Phosphoproteins detected to be differentially phosphorylated in the Ppp3r2 KO sperm population are either potential targets of GSK3 or calcineurin.
Phospho-protein | GSK3 phosphorylation consensus sites | Calcnineurin binding motif |
---|---|---|
S*/T*xxxS/T | LxVP; PxIxIT | |
MCT2 | ……S*KVGS*214RHDS218……T*VKAS469…… | NA |
Basigin | …..S*LNSS162…S*GEYS202…S*EHSS233…T283PEKS287….. | NA |
CatSper 1 | …T*HPGS18..S*EPLS*146HPSS150….S*TLAT260…S*ILTS474…T*LSGS485..T*TLFT429… | NA |
MIEF1 | ….S*APTS59…S*GCRS361… | NA |
CCNYL1 | …..T*IFLS99…..S*SCST131… | NA |
DRP1 | NA | …..L412FVP415…L632DVP635.. |