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α-secretase activity in pancreatic cancer. A. Expression data of TCGA-PAAD dataset showing the up-regulation of ADAM10, ADAM9 and ADAM17 in PDAC tumors. B. In-vitro FRET assay showing α-secretase activity was enhanced in PDAC tumors (n=30) compared to paired control tissues (n=30). C. Scatter plot showing the positive association between CD9 protein level and α-secretase activity (Pearson r=0.5797, P=0.0008) in PDAC tissues. For all, *P<0.05, ***P<0.001.
