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. 2020 Sep 15;12(9):5525–5537.

Figure 4.

Figure 4

CD9 directly interacts with ADAM family members in PDAC. A. Co-IP results showing CD9 protein levels precipitated by ADAM10, ADAM9 or ADAM17 antibody in PANC-1 cell line. B. Silver staining of purified recombinant GST-CD9 protein. C. GST pull-down showing the interaction of GST-CD9 with His tagged extracellular domains of ADAM10 (Thr214-Glu672), ADAM9 (Ala206-Asp697) or ADAM17 (Arg215-Asn671), respectively. D. GST pull-down showing that CD9 antibody blocked the interaction of GST-CD9 with His tagged extracellular domains of ADAM10, ADAM9 or ADAM17, respectively.