FOXA2 expression in metastatic PCa tissues. IHC staining of FOXA2 and synaptophysin was conducted on serial sections (A & B, C & D) derived from tissue microarray (UWTMA22). (A and B) PCa metastases in liver. (C and D) PCa metastases in bone. FOXA2 expression was detected in 28 sites, including 6/29 lymph node, 3/5 lung, 7/14 liver, 1/1 periaortic, and 11/75 bone metastases. Statistical analysis (Spearman Correlation test) indicates that FOXA2 expression has a significant positive correlation with SYP expression.