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FOXA2 knockdown decreases PC3 cells’ ability to grow in bone. PC3/Control (n=5) and PC3/FOXA2-KD (n=5) cells were injected into the tibiae of SCID mice. Animals were x-ray imaged weekly for 5 weeks and tumor progression with bone destruction was monitored. PC3/Control cells grew in all the bones injected and generated lytic bone lesions, whereas PC3/FOXA2-KD cells caused bone destruction in fewer tibia (Chi-Square test, P<0.001).
