Table 2.

Cyclin E-related tumor treatment

Drug/treatment	Function	Effect	Reference
Phenylpropanoid-based sulfonamides	Downregulate the expression of cyclin D1 and cyclin E	G1/S cell cycle arrest	[64]
Knockout of INMAP	Upregulates the expression of cyclin B and downregulates the expression of cyclin E	Postponement of mitotic exit and spindle assembly anomaly	[65]
Bufalin	Downregulates the expression of cyclin E and CDKs and upregulates the levels of p21 and p27	Tumorigenesis suppression	[66]
NRP-1 depletion	Downregulates the expression of cyclin E and CDKs and upregulates the levels of p21 and p27	G0/G1 cell cycle arrest	[67]
Ganoderiol F	Downregulates the expression of cyclin D, CDK4, CDK6, cyclin E and CDK2	G0/G1 cell cycle arrest	[68]
β-Cryptoxanthin	Reduces the expression of cyclin E, cyclin D1, and CDK4/6 and increases the expression of p53 and p21	G0/G1 cell cycle arrest	[69]
Trifluoperazine (TFP)	Downregulates the expression of CDK2/4 and cyclin D1/E and upregulates the expression of p27	G0/G1 cell cycle arrest	[70]
Metformin	Downregulates the expression of CCNE1/2 and CDK4/6	Tumor proliferation inhibition	[71]
XRRA1 low expression/silenced	Regulates the cyclin A, cyclin E, and p21 proteins	G2/M cell cycle arrest	[72]
VR23	Ubiquitinates cyclin E	Abnormal mitosis of tumor cells and cell cycle arrest	[73]
Fisetin:etoposide	Downregulates the expression of cyclin B1 and E1	Cell cycle arrest	[74]
miR-195	Targets cyclin E1	Reverses TMZ resistance	[78]
HuR	Downregulates the expression of cyclin E	G1 cell cycle arrest and induces apoptosis	[79]
CDK 2 inhibitor	Indirectly interferes with cyclin E1 function	Reverses chemoresistance	[81]
CCNE1/PIK3CA blockade	Targets cyclin E1 and Pik3ca mutation	Reverses trastuzumab resistance	[82]
Tehranolide	Modulates the PI3K/AKT signaling pathway and downregulates the expression of cyclin D1	G0/G1 cell cycle arrest	[83]
		G1/S cell cycle arrest