Association of lnc-MALAT1, miR-125b, FOXQ1, PTGS2 and CDK5 with 2-year MMSE score decline in AD patients. Correlation of CSF lnc-MALAT1 (A), miR-125b (B), FOXQ1 (C), PTGS2 (D) and CDK5 (E) with 2-year MMSE score decline in AD patients. Correlation of plasma lnc-MALAT1 (F), miR-125b (G), FOXQ1 (H), PTGS2 (I) and CDK5 (J) with 2-year MMSE score decline in AD patients. Correlation was analyzed by Spearman’s rank correlation test. Lnc-MALAT1, long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1; miR-125b, microRNA 125b; FOXQ1, forkhead box Q1; PTGS2, prostaglandin-endoperoxide synthase 2; CDK5, cyclin dependent kinase 5; MMSE, mini-mental state examination; CSF, cerebrospinal fluid; AD, Alzheimer’s disease.