Table 1.
Comparison of characteristics among AD patients, PD patients and Ctrls
| Items | AD patients (N = 120) | PD patients (N = 120) | Ctrls (N = 120) | P value |
|---|---|---|---|---|
| Age (years), mean ± SD | 70.1±7.1 | 68.6±6.6 | 69.0±7.2 | 0.217 |
| Gender, No. (%) | 0.228 | |||
| Male | 37 (30.8) | 49 (40.8) | 47 (39.2) | |
| Female | 83 (69.2) | 71 (59.2) | 73 (60.8) | |
| Education duration (years), median (IQR) | 5.0 (3.0-7.8) | 6.0 (4.0-9.0) | 8.0 (3.0-9.0) | 0.040 |
| CSF biomarkers, median (IQR) | ||||
| Aβ42 (pg/mL) | 346.2 (278.5-417.1) | 860.6 (731.5-1001.7) | 832.5 (727.7-960.7) | < 0.001 |
| t-tau (pg/mL) | 954.6 (766.0-1173.0) | 205.6 (181.1-258.5) | 239.2 (193.8-259.6) | < 0.001 |
| p-tau (pg/mL) | 124.9 (96.0-150.9) | 45.5 (38.2-54.4) | 49.7 (43.9-57.9) | < 0.001 |
| MMSE score, mean ± SD | 17.9±3.8 | 26.9±1.6 | 28.1±1.1 | < 0.001 |
Comparison was determined by one-way analysis of variance (ANOVA), Kruskal-Wallis H rank sum test or Chi-square test. AD, Alzheimer’s disease; PD, Parkinson’s disease; Ctrls, controls; SD, standard deviation; IQR, interquartile range; CSF, cerebrospinal fluid; Aβ42, amyloid β 42; t-tau, total tau; p-tau, phosphorylated tau; MMSE, mini-mental state examination.