Figure 2.

CD47 antibody attenuated ISO-induced cardiac dysfunction. A. Left ventricular (LV) function was measured by echocardiography. B. Echocardiography revealed significant impairment in LV function after ISO infusion, as evidenced by changes in EF; FS; LV mass; IVS, d; and LV vol. CD47 antibody treatment improved cardiac function. Data were analyzed by one-way ANOVA followed by Bonferroni’s post-hoc test and expressed as the mean ± SD, n=7 per group. Statistical significance: *P < 0.05 and **P < 0.01 versus the IgG group; #P < 0.05 and ##P < 0.01 versus the IgG+ISO group.