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The expression of collagen 2 and MMP-13 in rat knee cartilage by immunohistochemistry. (1) The expression of collagen 2 in the MIA+O3 group was higher than that in the MIA group. (2) The expression of MMP-13 in the MIA group and MIA+O3 group was higher than that in the Sham group, while the expression of MMP-13 in the MIA+O3 group was lower than that in the MIA group. *P<0.05, **P<0.01 vs. Sham; #P<0.05, ##P<0.01 vs. MIA.
