Relationships between the mRNAsi values and clinical characteristics. A. mRNAsi scores were higher in samples infected with HBV in the CGA HCC samples. B. mRNAsi scores were higher in iCluster3 compared to scores in iCluster1 and iCluster2 for all CGA HCC samples. C. mRNAsi scores were highest in iCluster3, and lowest in iCluster1, for CGA HCC samples without HBV infection. D. mRNAsi scores were highest for grade 3, and lowest for grade 1, for all CGA HCC samples. E. mRNAsi scores were highest for grade 3, and lowest for grade 1, for CGA HCC samples without HBV infection. F. For ICGC HCC samples, mRNAsi values increased with TNM staging only for the first three staging levels. G. There was no significant correlation between mRNAsi values and HBV infection for ICGC HCC samples. H. Immune scores were inversely related to mRNAsi scores in the CGA HCC samples. I. mRNAsi and mDNAsi values were positively correlated for CGA HCC samples. *P < 0.05. mRNAsi: mRNA gene expression-based stemness index; mDNAsi: DNA methylation-based stemness index; HBV: hepatitis B virus; CGA: Cancer Genome Atlas. ICGC: International Cancer Genome Consortium.