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. 2020 Sep 15;12(9):5955–5966.

Figure 2.

Figure 2

CD44 protein is expressed in colon cancer cell lines and its downregulation attenuates cell growth. A. CD44 protein expression in nine colon cancer cell lines by western blotting. SW480 and Lovo strongly expressed CD44s protein, whereas HT29 expressed CD44v protein. β-actin is used as an internal control. B. Downregulation of Pan-CD44 mRNA using siRNA in SW480 cells at 24 h. C. Downregulation of CD44 protein expression in SW480 cells (with CD44s protein) by siRNA at 48 h. D. Downregulation of CD44 expression inhibits cell growth in SW480 cells compared to control. E. Downregulation of CD44 protein expression in HT29 cells (with CD44v protein) by siRNA at 48 h. F. Downregulation of CD44 expression inhibits cell growth in HT29 cells compared to control.