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. 2020 Sep 15;12(9):5449–5464.

Figure 1.

Figure 1

LncRNA TUG1 was significantly up-regulated in degenerated intervertebral disc NP tissues. The expression of TUG1 (A) and miR-26a (B) were assessed by qRT-PCR in human disc NP tissues of LVF group (n=10) and IDD group (n=10). (C) The correlation between TUG1 and miR-26a expression in human disc NP tissues of IDD group by qRT-PCR. GAPDH and U6 were used as internal reference. (D) Immunohistochemistry was used to analyze the localization of HMGB1 in NP tissues. (E) Western blot assay was used to analyze the expression of HMGB1 protein in NP tissues. Bar =100 μm. The original images are available in Figure S2. (F) The relationship between HMGB1 and TUG1 or miR-26a in NP tissues of IDD group. Data are presented as mean ± standard deviation. *P<0.05, **P<0.01.