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. Author manuscript; available in PMC: 2021 Jul 24.

Published in final edited form as: J Nat Prod. 2020 Jul 10;83(7):2269–2280. doi: 10.1021/acs.jnatprod.0c00423

Table 3.

IC₅₀ Values and Selectivity of Cardenolides in TNBC Cell Lines

	IC₅₀ (μM) ± SEM
compound	BT-549	Hs578T	MDA-MB-231	SI^a
uzarigenin (1)	3.9 ± 0.4	3.6 ± 0.1	> 30	> 8
coroglaucigenin (2)	2.3 ± 0.3	1.8 ± 0.3	20 ± 4	9
desglucouzarin (3)	1.8 ± 0.2	1.57 ± 0.06	10 ± 1	6
frugoside (4)	0.121 ± 0.007	0.38 ± 0.06	1.25 ± 0.09	10
frugosidal (5)	1.4 ± 0.3	3.9 ± 0.9	10 ± 2	7
glucofrugoside (6)	0.070 ± 0.004	0.30 ± 0.05	0.98 ± 0.06	14
uscharin (7)	0.0146 ± 0.0001	0.034 ± 0.003	0.102 ± 0.004	7
calotoxin (8)	0.049 ± 0.002	0.12 ± 0.05	0.63 ± 0.04	13
calotropin (9)	0.030 ± 0.002	0.06 ± 0.01	0.44 ± 0.08	15

^a

Selectivity Index = IC₅₀ MDA-MB-231/ IC₅₀ BT-549