Table 4.

Pharmacokinetics of the four potential inhibitors.

Inhibitor	GIa	BBBp	P-gps	1A2	2C19	2C9	2D6	3A4	Log Kp
Schizanthine Y	High	No	No	No	No	No	No	No	−7.34
Schizanthine Z	High	No	No	No	No	No	No	No	−7.28
3	High	Yes	No	No	No	No	No	No	−6.65
4	High	Yes	No	No	No	No	No	No	−6.48