Table 2.
Characteristics of the patients included in the Covid-Clinic-Toul cohort until April 20, 2020 who died within the first 14 days of hospitalization.
| Patient | Age | Sex | Comorbidities | Time from first symptom to hospital admission | At hospital admission |
Limitation of life-sustaining treatments | ICU | Mechanical ventilation | Time from hospital admission to death | Cause of death | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Respiratory parameters | Biological findingsa | Chest CT-scan severity score | ||||||||||
| #1 | 81 | Male | Arterial hypertension, coronary disease, cerebrovascular disease, diabetes, immunosuppression (giant cell arteritis treated by corticosteroids) | 4 | SaO2 ≤ 92%, respiratory rate ≥ 22/min | Lymphopenia, thrombocytopenia, C-reactive protein ≥ 50 mg/L | Severe | Yes | No | No | 5 | ARDS |
| #2 | 90 | Male | Arterial hypertension, heart failure, coronary disease, current smoker | 7 | Need for oxygen, respiratory rate ≥ 22/min | Thrombocytopenia, C-reactive protein ≥ 50 mg/L | Severe | Yes | No | No | 6 | ARDS |
| #3 | 77 | Male | Glioblastoma, immunosuppression (chemotherapy, corticosteroids) | 4 | – | Lymphopenia | Moderate | Yes | No | No | 8 | ARDS |
| #4 | 85 | Female | Obesity, arterial hypertension, chronic lung disease (dermatomyositis, pulmonary fibrosis), cancer < 5 years, immunosuppression (corticosteroids) | 7 | Need for oxygen | Lymphopenia, thrombocytopenia, C-reactive protein ≥ 50 mg/L | Severe | Yes | No | No | 3 | ARDS |
| #5 | 87 | Male | Arterial hypertension, cerebrovascular disease | 3 | SaO2 ≤ 92%, respiratory rate ≥ 22/min | Lymphopenia, C-reactive protein ≥ 50 mg/L | Severe | Yes | Yes | No | 3 | ARDS |
| #6 | 49 | Male | Obesity | 8 | SaO2 ≤ 92%, respiratory rate ≥ 22/min | Lymphopenia, thrombocytopenia, C-reactive protein ≥ 50 mg/L | Moderate | No | Yes | Yes | 9 | ARDS, pulmonary embolism, sepsis |
| #7 | 79 | Female | Overweight, arterial hypertension, multiple myeloma, immunosuppression (chemotherapy) | 3 | SaO2 ≤ 92%, respiratory rate ≥ 22/min | Lymphopenia, thrombocytopenia, C-reactive protein ≥ 50 mg/L | Moderate | No | Yes | Yes | 8 | ARDS |
| #8 | 89 | Male | Arterial hypertension, COPD, chronic kidney disease | 3 | Respiratory rate ≥ 22/min | Lymphopenia, thrombocytopenia, C-reactive protein ≥ 50 mg/L | Moderate | Yes | No | No | 9 | ARDS, acute heart failure |
| #9 | 83 | Female | Obesity, arterial hypertension, heart failure, coronary disease, sleep apnea, chronic kidney disease, diabetes, giant cell arteritis, immunosuppression (corticosteroids) | 4 | Need for oxygen | Lymphopenia, C-reactive protein ≥ 50 mg/L | Moderate | Yes | Yes | No | 3 | ARDS, sepsis |
| #10 | 93 | Male | Obesity, arterial hypertension, heart failure, sleep apnea, chronic respiratory disease | 1 | SaO2 ≤ 92%, respiratory rate ≥ 22/min | – | Moderate | Yes | No | No | 7 | ARDS, acute heart failure |
| #11 | 85 | Male | Overweight, arterial hypertension, coronary disease | 8 | – | Lymphopenia, C-reactive protein ≥ 50 mg/L | Mild | No | Yes | Yes | 8 | ARDS |
| #12 | 67 | Male | Arterial hypertension | 2 | Need for oxygen | Lymphopenia, thrombocytopenia, C-reactive protein ≥ 50 mg/L | No typical sign | No | Yes | Yes | 5 | ARDS |
| #13 | 92 | Female | Cerebrovascular disease | 2 | – | Lymphopenia | No typical sign | Yes | No | No | 11 | ARDS, sepsis, acute heart failure |
| #14 | 92 | Female | Overweight, heart failure, cerebrovascular disease, pulmonary arterial hypertension, chronic kidney disease | 7 | SaO2 ≤ 92%, respiratory rate ≥ 22/min | Thrombocytopenia, C-reactive protein ≥ 50 mg/L | Severe | Yes | No | No | 4 | ARDS |
| #15 | 78 | Female | Overweight, arterial hypertension, asthma, pulmonary arterial hypertension | 2 | SaO2 ≤ 92%, respiratory rate ≥ 22/min | Lymphopenia, thrombocytopenia, C-reactive protein ≥ 50 mg/L | Moderate | Yes | No | No | 4 | ARDS, pulmonary embolism |
| #16 | 79 | Female | Obesity, arterial hypertension, chronic kidney disease, diabetes | 1 | Need for oxygen | Lymphopenia, thrombocytopenia | – | No | Yes | Yes | 9 | ARDS |
| #17 | 68 | Female | Obesity, arterial hypertension, breast cancer, immunosuppression (chemotherapy) | 7 | Need for oxygen, respiratory rate ≥ 22/min | Lymphopenia, C-reactive protein ≥ 50 mg/L | Moderate | Yes | No | No | 5 | ARDS, pulmonary embolism, acute heart failure |
| #18 | 61 | Female | Obesity, arterial hypertension, COPD, sarcoidosis, diabetes, immunosuppression (immunosuppressants) | 4 | Respiratory rate ≥ 22/min | Lymphopenia | Mild | Yes | No | No | 12 | ARDS |
| #19 | 86 | Female | Overweight, arterial hypertension | NA | Respiratory rate ≥ 22/min | Lymphopenia, thrombocytopenia, C-reactive protein ≥ 50 mg/L | Severe | Yes | No | No | 8 | ARDS |
ARDS: acute respiratory distress syndrome; COPD: chronic obstructive pulmonary disease; ICU: intensive care unit; NA: not available.
a
Lymphopenia was defined by lymphocyte count < 1.5 G/L; thrombocytopenia was defined by platelet count < 150 × 109/L.