Table 2.
Effect of different dosage of IONPs on the activity of LFT & RFT in Wistar rat at day 28
| Tests | Control | Vehicle control | Low dose | Medium dose | High dose |
|---|---|---|---|---|---|
| LFT | |||||
| Total bilirubin (mg/dL) | 0.4 ± 0.05 | 0.4 ± 0.1 | 3.2 ± 0.1 | 0.9 ± 0.3 | 0.9 ± 0.5 |
| Direct bilirubin (mg/dL) | 0.4 ± 0.09 | 0.5 ± 0.05 | 2.1 ± 3.0 | 0.6 ± 0.2 | 0.5 ± 0.1 |
| SGOT (mg/dL) | 237.2 ± 85.1 | 248 ± 18.4 | 272.6 ± 2.1 | 336 ± 33.0 | 262.5 ± 34.8 |
| Total protein (g/dL) | 7.9 ± 0.4 | 8.5 ± 0.6 | 9.4 ± 2.1 | 7.5 ± 0.7 | 8.2 ± 0.3 |
| Albumin (g/dL) | 4 ± 0.5 | 4.3 ± 0.2 | 6.9 ± 0.5 | 6.6 ± 0.2 | 5.5 ± 0.2 |
| Globulin (g/dL) | 3.7 ± 0.2 | 4.2 ± 0.5 | 2.5 ± 0.4 | 2.64 ± 0.5 | 2.6 ± 0.1 |
| Alkaline phosphate (mg/dL) | 168.1 ± 33.8 | 93.9 ± 21.5 | 50.9 ± 51.8 | 129.5 ± 31.4 | 99.5 ± 26.6 |
| SGPT (mg/dL) | 55.8 ± 2.9 | 52 ± 3.6 | 64.5 ± 4.4 | 72.3 ± 6.5 | 42.3 ± 2.5 |
| RFT | |||||
| BUN (mg/dL) | 16.3 ± 2.9 | 15.3 ± 1.5 | 20.7 ± 0.6 | 17.3 ± 1.0 | 21.7 ± 1.6 |
| Urea (mg/dL) | 2.6 ± 6.4 | 31.4 ± 1.2 | 44.3 ± 1.2 | 37 ± 2.0 | 46.5 ± 3.4 |
| Creatinine (mg/dL) | 1.1 ± 0.2 | 1.1 ± 0.2 | 0.9 ± 0.1 | 0.9 ± 0.1 | 1.2 ± 0.1 |
| Uric acid (mg/dL) | 3.6 ± 1.1 | 3.8 ± 0.3 | 8.7 ± 2.0 | 6.4 ± 1.5 | 3 ± 1.1 |