Figure 2.

Midazolam, 1′‐OH‐midazolam, progestin, and EE concentrations in plasma after single dose administration of the test drug with and without co‐administration of rifampicin. Geometric means and standard deviations. (a) Midazolam concentration vs. time; (b) 1′‐OH‐midazolam concentration vs. time; (c) unbound levonorgestrel concentration vs. time; (d) unbound norethindrone concentration vs. time; (e) unbound etonogestrel (active metabolite of desogestrel) concentration vs. time; (f) dienogest concentration vs. time; (g) drospirenone concentration vs. time; (h) ethinylestradiol concentration vs. time. LLOQ, lower limit of quantitation; RIF, rifampicin.