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. 2020 May 11;108(4):798–807. doi: 10.1002/cpt.1848

Figure 6.

Figure 6

Rifampicin‐dependent induction relationship between 4ß‐hydroxycholesterol and midazolam, different progestins, and ethinylestradiol. The magnitude of the induction effect on the progestins and MDZ is classified into three categories: weak induction (W, > 0.5 and ≤ 0.8), moderate induction (M, > 0.2 and ≤ 0.5) and strong induction (S, ≤0.2). 4ß‐OH, 4ß‐hydroxycholesterol; AUC, area under the concentration‐time curve extrapolated to infinity; CI, confidence interval; DNG, dienogest; DRSP, drospirenone; EE, ethinylestradiol; ENGunbound, unbound etonogestrel (active metabolite of desogestrel); GMR, geometric mean ratio; LNGunbound, unbound levonorgestrel; MDZ, midazolam; NETunbound, unbound norethindrone.