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. 2020 Jul 29;59(39):17062–17069. doi: 10.1002/anie.202006577

Figure 1.

Figure 1

[5‐19F, 5‐13C]‐pyrimidine RNA building blocks and target RNAs. a) [5‐19F, 5‐13C]‐uridine and b) [5‐19F, 5‐13C]‐cytidine phosphoramidite building blocks 7 and 11 suitable for RNA production via solid phase synthesis. c) HIV TAR 2 RNA 12 with 30 nucleotides (nts) and a molecular weight of approx. 10 kD. d) hHBV ϵ RNA 13 with 61 nts and a molecular weight of approx. 20 kD. e) SAM VI metK aptamer domain 14 with 49 nts, the S‐adenosyl‐l‐methionine ligand is shown. f) The 59 nt pre‐miRNA 21 15 and the apical stem loop subsegment 15 a. Fluorine is highlighted in green, orange dot=13C, [19F,13C]‐modified residues highlighted in green.