FIGURE 1.

Logistics of rapid prenatal diagnostic testing in the study setting. Panel A (top) shows a realistic, common scenario of inclusion for a fetus with ultrasound anomalies. The collection of fetal material via chorionic villus sampling/amniocentesis is typically scheduled on fixed days of the week, which allows the subsequent genetic diagnostic workflow to be scheduled, including QF‐PCR, SNP‐array, and rES. Panel B (bottom) shows the observed delays in the workflow with the additional time spent on such delays in days. MDT, multidisciplinary team; QF‐PCR, quantitative fluorescent‐polymerase chain reaction; rES, rapid exome sequencing; SNP‐array, single nucleotide polymorphism‐array [Colour figure can be viewed at wileyonlinelibrary.com]