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. 2020 Aug 6;80(14):1233–1243. doi: 10.1002/pros.24050

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© 2020 The Authors. The Prostate Published by Wiley Periodicals LLC

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Comparison of IC₅₀ for both patient's tumor and normal CR cells exposed to drugs ranked by DrugGenEx‐Net. IC₅₀ calculations performed on the CR cells exposed to (A) CFZ and BTZ or (B) SFN or PTC for 72 hour. ³² : molar. (C and D) Detailed dose‐response curves of the CR cells from patient 1 treated with CFZ or BTZ, respectively. (E and F) Detailed dose‐response curves of the CR cells from patient 2 treated with CFZ or BTZ, respectively All values are the average ± SD of three separate experiments performed in triplicate. BTZ, bortezomib; CFZ, carfilzomib; CR, conditionally reprogrammed; PTC, phenethyl isothiocyanate; SFN, sulforaphane [Color figure can be viewed at wileyonlinelibrary.com]