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. 2020 Aug 6;80(14):1233–1243. doi: 10.1002/pros.24050

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© 2020 The Authors. The Prostate Published by Wiley Periodicals LLC

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Differential effects of CFZ treatment on gene expression. A, Impact of CFZ on proteasomal subunit genes in the CR cells from patient 1. B, Impact of CFZ on serine proteases and metalloproteases in CR cells from patient 1. Differential effects of CFZ treatment on (C) proteasomal subunits and (D) serine proteases and metalloproteases in CR cells from patient 2. CFZ, carfilzomib; CR, conditionally reprogrammed; DMSO, dimethyl sulfoxide; FC, fold change [Color figure can be viewed at wileyonlinelibrary.com]