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. 2020 Aug 6;80(14):1233–1243. doi: 10.1002/pros.24050

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© 2020 The Authors. The Prostate Published by Wiley Periodicals LLC

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Genes exclusively regulated by CFZ in normal and tumor CR cells. A, Venn diagram of the sets of genes induced (FC 1.5; FDR 0.05) by CFZ in the CR cells from patients 1 and 2. *Induced genes shared between the tumor‐derived cells. **Induced genes shared between the normal cells. B, Venn diagram of the sets of inhibited genes (FC 1.5; FDR 0.05) by CFZ in the CR cells from patients 1 and 2. *Inhibited genes shared between the tumor‐derived cells. **Inhibited genes shared between the = normal cells (C) Ingenuity Pathway Network analyses of the genes that were regulated by CFZ exclusively in the tumor‐derived CR cells. CFZ, carfilzomib; CR, conditionally reprogrammed; FC, fold change; FDR, False Discovery Rate [Color figure can be viewed at wileyonlinelibrary.com]