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Substitution of highly conserved amino acids under purifying selection leads to genome elimination. Plot of SIFT (sorting intolerant from tolerant) scores against percent haploid induction (a) and percent seed death (b). The red line indicates the SIFT score of 0.05. Amino acid substitutions with a SIFT score of 0.05 are generally predicted to be intolerant and the substitutions with a score of 0.05 and higher are predicted to be tolerated.
