Table 3.

Testing, Selection, and Parameter Estimates for C_max,ss Base Model

Model No.	Model	AIC	Comparison	P Value
1	$\mathrm{C}{\max }_{\mathrm{ss},\mathrm{i}}={\beta }_0\times \mathrm{Oint}\mathrm{Dos}{\mathrm{e}}_{\mathrm{i}}$	2928.9	‐	‐
2	$\mathrm{Cma}{\mathrm{x}}_{\mathrm{ss},\mathrm{i}}=({\beta }_0\times {(\frac{\mathrm{W}{\mathrm{t}}_{\mathrm{i}}}{70})}^{\gamma })\times \mathrm{Oint}\mathrm{Dos}{\mathrm{e}}_{\mathrm{i}}$	2919.4	Model 1 versus 2	<0.001
	Selected Base Model Parameter	Estimate	Lower 95%CI	Upper 95%CI
	β0 (ng·h/mL/mg)	0.0025	0.0021	0.0029
	γ	−0.9885	−1.2880	−0.5561

AIC indicates Akaike information criteria; β₀, slope; C_max,ss, mean maximum concentration at steady state; γ, exponent; Oint Dose_i, ointment dose for i_th participant in milligrams; Wt_i, body weight for i_th participant in kilograms.