Table 4.
Parameter Estimates for AUCss and Cmax,ss Final Models
| Parameter | Estimate | RSE, % | Median (95%CI) a |
|---|---|---|---|
| AUCss final model | |||
| β0 (ng·h/mL/mg) | 0.0178 | 4.26 | 0.0177 (0.0164‐0.0192) |
| γ (effect of body weight) | −0.75 (fixed) | – | – |
| GE (effect of sex, female) | 0.7536 | 6.16 | 0.7528 (0.6607‐0.8593) |
| RC (effect of race/ethnicity, other) | 0.7046 | 7.63 | 0.7057 (0.6168‐0.8234) |
| DISad (effect of disease, atopic dermatitis) | 2.5451 | 8.91 | 2.5329 (2.1369‐3.0034) |
| ADms (effect of atopic dermatitis severity, moderate) | 0.7542 | 10.5 | 0.7610 (0.6237‐0.9161) |
| DISps (effect of disease, psoriasis) | 2.5051 | 10.7 | 2.5105 (2.0758‐3.0894) |
| PSOse (effect of psoriasis disease severity, severe) | 1.2800 | 11.2 | 1.2862 (1.0516‐1.5913) |
| Cmax,ss final model | |||
| β0 (ng·h/mL/m) | 0.0022 | 4.63 | 0.0022 (0.0020‐0.0024) |
| γ (effect of body weight) | 0.4387 | 21.6 | 0.4436 (0.2544‐0.6203) |
| GE (effect of sex, female) | 0.7716 | 6.79 | 0.7742 (0.6686‐0.8870) |
| RC (effect of race/ethnicity, other) | 0.7681 | 7.42 | 0.7673 (0.6595‐0.8839) |
| DISad (effect of disease, atopic dermatitis) | 2.6459 | 9.33 | 2.6401 (2.1968‐3.1571) |
| DISps (effect of disease, psoriasis) | 2.4732 | 10.8 | 2.4801 (2.0004‐3.0592) |
| PSOse (effect of psoriasis disease severity, severe) | 1.2842 | 10.7 | 1.2838 (1.0276‐1.5993) |
AUCss indicates area under concentration‐time curve at steady state; Cmax,ss, mean maximum concentration at steady state; RSE, relative standard error.
a
Median and 95%CIs were obtained from a nonparametric bootstrap procedure for the final model.