TABLE 3.

Summary of activity/motor function results across the ASD animal models studied

	Activity/motor function
	Standard open field				Distance moved			SmartCube a				Neonatal		NeuroCube
Gene/copy number variation	Distance moved	Rearing	Time in center	Distance in center	Social interaction	Urine open field baseline	Marble‐burying	Time mobile	Supported rearing time	Abrupt movement frequency	Short step frequency	Pup righting	Pup rolling	Gait	Average speed
SHANK3/F KO	↓	↓	↓	↓	↓↓^	≈↓	↓	↓↓	↓↓	≈ ↓	↓↓	≈	≈	≈	↑
SHANK3/J KO	‐	‐	‐	‐	↓	≈	≈	≈	≈	≈	≈	≈	≈	≈	↑
Cacna1c HET	‐	‐	‐	‐	↓	↓	≈	↓	≈	↓	≈	≈	≈	≈	≈
16p11.2 HET	‐	‐	‐	‐	≈	≈	↑	≈	≈	≈	↑	↓	≈	↓	↑^
Cntnap2 KO	↓	≈	≈	≈	≈≈	≈↓^	≈	↑↑	≈≈	↑↑	↑↑	↓	↑	↓	↑

Note: Directions of effects are shown comparing each model system to their corresponding WT controls across the three studies (upward arrow: increased, downward arrow: decreased, ≈: no difference, ^: non‐significant trend). Two symbols occupying a single cell reflect both the original study and replication results. “‐” indicates no data collected for that model.

Abbreviations: ASD, autism spectrum disorder; HET, heterozygous; KO, knockout; WT, wild type.

^aQuantitative measure (see the description of test assessment in Methods).