TABLE 4.

Summary of social behavioral results across the ASD animal models studied

	Social
	Three chamber		Reciprocal social interaction							Urine‐exposure open field
Gene/copy number variation	Sociality	Recognition	Proximity time	Proximity distance	Following time	Interaction count	Interaction time	Reciprocal interaction time	Ultrasonic vocalizations	Marking count baseline	Marking count exposure	Marking count center exposure	Distance moved baseline	Distance moved exposure	Distance moved center baseline	Distance moved center exposure	Center time baseline	Center time exposure	Ultrasonic vocalizations
SHANK3/F KO	↓	↓	↑↑	↓↓	↓↓	↓↓	↑↑	↑↑	≈↓	≈≈	≈≈	≈↓	≈↓	↓↓	≈↓	↓↓	↓↓	↓↓	↓↓
SHANK3/J KO	≈	≈	≈	≈	↓	≈	↑	≈	≈	≈	≈	≈	≈	≈	≈	≈	↓	↓	↓
Cacna1c HET	≈	≈	↑	≈	↓	≈	↑	≈	≈	≈	≈	≈	↓	↓	↓	↓	≈	↓	≈
16p11.2 HET	≈	≈	≈	↓	≈	≈	↑	≈	≈	≈	≈	≈	≈	↑	≈	≈	↑	≈	≈
Cntnap2 KO	≈	≈	≈≈	≈≈	≈≈	≈≈	≈↓	≈≈	≈≈	↓≈	≈≈	≈≈	≈↓	↑≈	≈≈	≈↓	≈≈	≈↓	↓↓

Note: Directions of effects are shown comparing each model system to their corresponding WT controls (upward arrow: increased, downward arrow: decreased, ≈: no difference, dashed shorter arrow: non‐significant trend). Two symbols occupying a single cell reflect both the original study and replication results.

Abbreviations: ASD, autism spectrum disorder; HET, heterozygous; KO, knockout; WT, wild type.