Table 5.
Geometric Mean Ratios of CLB and N‐CLB Pharmacokinetic Parameters on Day 33 Compared With Day 1; Pharmacokinetic Analysis Set
| Placebo | CBD | |
|---|---|---|
| (n = 3) | (n = 10) | |
| Day 33:Day 1 Ratio (90%CI) | ||
| Parameter | CLB | |
| Cmax | 1.1 (0.4‐2.7) | 1.0 (0.8‐1.2) |
| AUCtau | 1.0 (0.7‐1.5) | 1.1 (0.9‐1.2) |
| N‐CLB | ||
|---|---|---|
| Cmax | 1.2 (0.6‐2.2) | 2.2 (1.4‐3.5) |
| AUCtau | 1.0 (0.8‐1.3) | 2.6 (2.0‐3.6) |
AUCtau, area under the plasma concentration‑time curve over a dosing interval, where tau is the dosing interval; CBD, cannabidiol; CI, confidence interval; CLB, clobazam; Cmax, maximum measured plasma concentration; N‐CLB, N‐desmethylclobazam.