TABLE 2.

International comparison of Parkinson's disease cohorts that performed full GBA1 gene sequencing, sorted based on total percent of GBA1 variant carriers [Color table can be viewed at wileyonlinelibrary.com]

International comparison of total and common GBA1 variants in Parkinson's disease cohorts
	PD (n)	GBA1 (%)	E326K	T369M	N370S	L444P	D140H + E326K	Other
Ashkenazi Jewish	735	18.0	1.6	0	11.8	0.3	0	4.2
This cohort (NL)	3402	15.0	6.7	2.5	0.9	0.6	2.5	1.8
France	1130	12.5	4.2	1.5	2.9	1	0.1	2.7
Colombia	131	12.2	1.5	0	2.3	2.3	0	6.1
Norway	442	12.0	6.6	3.6	0.2	1.4	0	0.5
Spain	532	11.7	3	0.9	0.9	2.4	0	4.3
United States	1369	11.6	5	2.2	1.3	1.2	0.1	1.9
United Kingdom	1893	11.1	4.5	1.8	0.6	1.6	0.1	2.4
Eastern Canada	225	11.1	1.8	4.9	0.9	1.8	0	1.8
Belgium	266	9.8	4.1	1.1	1.1	1.5	0.4	1.5
Japan	534	9.4	0	0	0	4.1	0	5.2
New Zealand	229	9.2	4.8	3.1	0.4	0	0.4	0.9
Sweden	1625	8.3	5.8	N/A	0.4	2.2	N/A	N/A
Peru	471	7.2	1.1	0.6	0.2	2.8	0	1.8
Russia	762	6.6	2.4	2.5	0.5	1.1	N/A	N/A
Greece	172	6.4	0.6	0	0	1.2	0	4.7
Portugal	230	6.1	0.9	0.9	2.2	1.3	0	0.9
Korea	277	6.1	0	0	0	0.7	0	5.4
North Africa	194	4.6	0.5	1.0	1.0	1.5	0	0.5

PD, Parkinson's disease; NL, the Netherlands; N/A, not applicable.

All variant frequencies are given in percentages. Sweden and Russia performed selective sequencing. France is a European study, with 89% of subjects from France. North Africa is primarily Algeria, but also Morocco, Tunisia, and Libya. References: Ashkenazi Jewish (1), Netherlands (current study), France (2), Colombia (3), Norway (4), Spain (5), United States (6), United Kingdom (7), eastern Canada (8), Belgium (9), Japan (10), New Zealand (11), Sweden (12), Peru (3), Russia (13), Greece (14), Portugal (15), Korea (16), and north Africa (17).