FIGURE 5.

Prolonged treatment with olcegepant worsens the outcomes after 60‐minute focal cerebral ischemia. (A) Experimental timeline. (B) Infarct volume (mm³) and neurologic deficit scores (p < 0.001 and p = 0.007, respectively, 2‐way analysis of variance). Data from individual animals are shown along with their group mean for infarct and median for neurologic score (red lines). All mice were 2 months old, male, and wild type. Two mice in the vehicle (Veh) and 3 mice in the olcegepant (Olce) 0.1mg/kg and olcegepant 1mg/kg arms died prior to outcome assessments. There were no exclusions. [Color figure can be viewed at www.annalsofneurology.org]