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. 2020 Jul 8;47(10):1713–1722. doi: 10.1111/1440-1681.13309

Figure 2.

Figure 2

Diosmetin enhances anti‐cardiomyocyte apoptosis in MI model rats. A, Comparison of caspase‐3 expressions in myocardial cells detected by immunohistochemical staining from sham group, MI model group, low‐dose group, medium‐dose group and high‐dose group. Magnification 200×. B, Semi‐quantitative analysis of the relative amounts of caspase‐3 in each group of neonatal rats. C, Relative mRNA level of MDM2 and p53 detected by RT‐qPCR in each group of neonatal rats. D, A representative result for western blot analysis MDM2 and p53. E, Semi‐quantitative analysis of the relative level of MDM2 and p53 in each group of neonatal rats. The results were presented as mean ± SD and represent three individual experiments. (*P < .05 vs sham group, #P < .05 vs MI model group, ##P < .01 vs MI model group) Inline graphic, Control; Inline graphic, MI model; Inline graphic, Diosmetin 50; Inline graphic, Diosmetin 100; Inline graphic, Diosmetin 200; Inline graphic, Control; Inline graphic, MI model; Inline graphic, Diosmetin 50; Inline graphic, Diosmetin 100; Inline graphic, Diosmetin 200; Inline graphic, Control; Inline graphic, MI model; Inline graphic, Diosmetin 50; Inline graphic, Diosmetin 100; Inline graphic, Diosmetin 200