Table 4.

Kittens' clinical chemistry parameters at the study completion following AOCED exposure starting in utero until the 32 weeks of age

Parameter	Sex	Control	Low‐dose AOCED	Mid‐dose AOCED	High‐dose AOCED
A/G ratio	M	1.56 ± 0.19	1.42 ± 0.11	1.48 ± 0.15	1.50 ± 0.16
	F	1.46 ± 0.21	1.42 ± 0.08	1.36 ± 0.09	1.38 ± 0.16
ALP (U/L)	M	76.00 ± 16.99	63.00 ± 7.35	73.80 ± 21.15	58.40 ± 16.89
	F	58.40 ± 12.24	48.60 ± 7.77	57.00 ± 12.04	42.20 ± 5.36
ALT (U/L)	M	90.60 ± 20.03	100.00 ± 25.78	88.60 ± 14.31	96.80 ± 30.38
	F	71.80 ± 17.12	78.40 ± 22.19	86.20 ± 24.79	89.00 ± 13.58
AST (U/L)	M	36.20 ± 19.87	30.40 ± 4.93	29.80 ± 6.76	32.00 ± 5.61
	F	25.60 ± 5.03	27.20 ± 5.59	32.60 ± 6.50	28.20 ± 5.07
Albumin (g/dl)	M	3.90 ± 0.16	3.64 ± 0.23	3.66 ± 0.18	3.70 ± 0.34
	F	3.84 ± 0.09	3.76 ± 0.13	3.58 ± 0.18	3.74 ± 0.09
Amylase (U/L)	M	766.80 ± 118.67	741.40 ± 86.25	710.60 ± 110.24	813.00 ± 112.25
	F	676.00 ± 106.64	691.60 ± 86.56	684.60 ± 59.00	705.80 ± 97.91
Bile acids	M	1.00 ± 1.00	0.40 ± 0.55	0.40 ± 0.55	0.20 ± 0.45
	F	0.60 ± 0.55	0.40 ± 0.55	0.20 ± 0.45	0.20 ± 0.45
Calcium (mg/dl)	M	10.60 ± 0.29	10.12 ± 0.41	10.16 ± 0.21	10.08 ± 0.18
	F	10.20 ± 0.24	10.08 ± 0.28	10.08 ± 0.29	10.14 ± 0.11
Chloride (mEq/L)	M	113.00 ± 1.58	113.20 ± 2.77	114.80 ± 2.17	113.40 ± 1.14
	F	114.60 ± 1.67	115.00 ± 1.87	115.40 ± 1.82	115.80 ± 1.92
Cholesterol (mg/dl)	M	176.00 ± 52.40	152.80 ± 11.95	146.80 ± 23.04	132.40 ± 18.51
	F	158.20 ± 20.64	167.20 ± 17.92	151.40 ± 23.07	141.20 ± 23.00
Creatine kinase (U/L)	M	305.20 ± 111.74	308.80 ± 145.05	368.20 ± 171.05	365.60 ± 162.75
	F	381.60 ± 204.99	237.00 ± 80.16	409.80 ± 238.92	286.40 ± 179.24
Creatinine (mg/dl)	M	0.98 ± 0.19	0.86 ± 0.11	1.02 ± 0.04	1.00 ± 0.19
	F	0.92 ± 0.11	0.90 ± 0.07	1.02 ± 0.11	0.92 ± 0.08
GGT (U/L)	M	0 ± 0	0 ± 0	0 ± 0	0 ± 0
	F	0 ± 0	0 ± 0	0 ± 0	0 ± 0
Globulins (g/dl)	M	2.50 ± 0.23	2.58 ± 0.19	2.50 ± 0.19	2.50 ± 0.14
	F	2.66 ± 0.34	2.66 ± 0.21	2.66 ± 0.21	2.76 ± 0.36
Glucose (mg/dl)	M	80.00 ± 6.82	82.60 ± 9.15	80.00 ± 4.47	88.40 ± 3.97
	F	85.20 ± 9.31	88.60 ± 12.78	78.20 ± 7.46	79.00 ± 6.28
LDH (U/L)	M	199.40 ± 30.92	116.80 ± 39.13	177.00 ± 42.94	150.40 ± 35.40
	F	154.80 ± 18.35	112.40 ± 34.41	171.80 ± 40.03	134.80 ± 69.68
Magnesium (mEq/L)	M	2.00 ± 0.07	1.84 ± 0.09	1.90 ± 0.00	1.94 ± 0.11
	F	1.90 ± 0.10	1.84 ± 0.09	1.88 ± 0.08	1.90 ± 0.12
Phosphate (mg/dl)	M	7.50 ± 0.86	7.06 ± 0.84	7.04 ± 0.18	6.92 ± 0.55
	F	6.16 ± 0.51	6.06 ± 0.35	6.22 ± 0.33	5.82 ± 0.36
Potassium (mEq/L)	M	4.68 ± 0.22	4.42 ± 0.28	4.46 ± 0.21	4.30 ± 0.20
	F	4.44 ± 0.23	4.10 ± 0.29	4.32 ± 0.34	4.24 ± 0.35
Sodium (mEq/L)	M	154.20 ± 1.10	153.40 ± 1.82	154.00 ± 1.87	152.60 ± 0.89
	F	153.80 ± 1.10	153.00 ± 1.41	152.20 ± 1.10	152.40 ± 1.14
Taurine (nMol/ml)	M	510.80 ± 85.15	420.20 ± 55.45	415.80 ± 67.87	635.50 ± 55.86
	F	481.80 ± 101.80	362.60 ± 67.89	444.80 ± 101.12	351.00 ± 40.09
Total bilirubin (mg/dl)	M	0 ± 0	0.02 ± 0.04	0 ± 0	0 ± 0
	F	0 ± 0	0 ± 0	0 ± 0	0 ± 0
Total protein (g/dl)	M	6.40 ± 0.31	6.22 ± 0.36	6.16 ± 0.23	6.20 ± 0.38
	F	6.50 ± 0.22	6.42 ± 0.29	6.24 ± 0.32	6.50 ± 0.35
Triglycerides (mg/dl)	M	35.40 ± 8.99	35.40 ± 5.55	27.60 ± 7.16	63.80 ± 77.47a
	F	29.20 ± 6.02	26.00 ± 5.48	25.20 ± 3.63	26.00 ± 5.92
Urea nitrogen (mg/dl)	M	27.20 ± 3.63	23.60 ± 1.14	23.40 ± 2.30	24.60 ± 4.67
	F	25.60 ± 3.97	28.00 ± 4.30	26.20 ± 1.30	25.80 ± 2.39

Values are given as mean ± SD (n = 5 in each group).

^aOne individual with a high triglyceride level (220), increasing the mean and SD.