Figure 9.

Outcome of wet‐chemical approach towards eight‐fold γ–ortho cyclization. a) Best result achieved in a microwave reactor with 8, [Pd(PCy₃)₂Cl₂] (8 equiv), DMAc/DBU (4:1, v:v), N₂, 180 °C, 4 h; then silica gel plug filtration. b) Enlargement of the mass spectrum of the reaction outcome (simulation suggests a mixture of [8Pd−5 HCl−3 Cl+3 H]⁺/[8Pd−4 HCl−4 Cl+H]⁺/[8Pd−3 HCl−5 Cl+5 H]⁺/[8Pd−2 HCl−6 Cl+6 H]⁺/[8Pd−1 HCl−7 Cl+7 H]⁺=1:7:5:4:4. c) Normalized UV/Vis spectra of 8, 8Pd, and the isolated reaction outcome.