TABLE 3.
ICRS grades 4 and 12 weeks after transplantation
| Item | A | B | C | D | |
|---|---|---|---|---|---|
| 4W | Ti | 2.1 ± 0.7 | 3.5 ± 0.5 | 1.8 ± 0.2 | 2.1 ± 0.6 |
| Matx | 1.3 ± 0.4 | 2.4 ± 0.8 | 1.8 ± 0.3 | 1.6 ± 0.5 | |
| Stru | 2.3 ± 0.6 | 3.7 ± 0.5 | 1.9 ± 0.1 | 2.4 ± 1.1 | |
| Clus | 1.0 ± 0.0 | 1.1 ± 0.1 | 1.0 ± 0.0 | 1.0 ± 0.0 | |
| Tide | 1.0 ± 0.0 | 2.2 ± 1.1 | 1.0 ± 0.0 | 1.2 ± 0.4 | |
| Bform | 2.4 ± 0.4 | 2.3 ± 0.4 | 1.0 ± 0.0 | 1.4 ± 0.6 | |
| SurfH | 2.4 ± 0.6 | 2.8 ± 0.8 | 2.0 ± 0.3 | 2.0 ± 0.6 | |
| FilH | 3.5 ± 0.9 | 3.9 ± 0.9 | 3.6 ± 0.9 | 3.3 ± 1.3 | |
| Latl | 1.7 ± 0.8 | 2.4 ± 0.5 | 2.4 ± 0.6 | 1.9 ± 0.7 | |
| Basl | 1.9 ± 0.8 | 3.1 ± 1.0 | 3.4 ± 1.1 | 2.7 ± 0.9 | |
| InfH | 5.0 ± 0.0 | 5.0 ± 0.0 | 5.0 ± 0.0 | 5.0 ± 0.0 | |
| Hgtot | 24.6 ± 4.1 | 32.3 ± 5.4 | 24.9 ± 3.2 | 25.2 ± 5.9 | |
| Item | A | B | C | D | |
| 12W | Ti | 1.7 ± 0.4 | 3.0 ± 0.9 | 1.9 ± 0.1 | 1.9 ± 0.1 |
| Matx | 1.2 ± 0.4 | 2.4 ± 1.3 | 1.3 ± 0.5 | 1.5 ± 0.5 | |
| Stru | 2.2 ± 0.7 | 2.9 ± 0.8 | 1.9 ± 0.5 | 2.2 ± 0.3 | |
| Clus | 1.1 ± 0.1 | 1.1 ± 0.1 | 1.0 ± 0.0 | 1.0 ± 0.0 | |
| Tide | 1.0 ± 0.0 | 2.2 ± 1.2 | 1.0 ± 0.0 | 1.0 ± 0.0 | |
| Bform | 2.8 ± 0.2 | 2.6 ± 0.5 | 1.3 ± 0.6 | 1.4 ± 0.5 | |
| SurfH | 2.1 ± 0.6 | 3.1 ± 0.5 | 1.9 ± 0.5 | 2.4 ± 0.6 | |
| FilH | 3.4 ± 0.8 | 5.0 ± 0.0 | 3.1 ± 0.6 | 3.6 ± 0.7 | |
| Latl | 1.5 ± 0.8 | 2.6 ± 0.4 | 1.7 ± 0.5 | 1.9 ± 0.6 | |
| Basl | 1.5 ± 0.6 | 3.6 ± 0.6 | 3.1 ± 0.6 | 3.3 ± 0.6 | |
| InfH | 5.0 ± 0.0 | 5.0 ± 0.0 | 5.0 ± 0.0 | 5.0 ± 0.0 | |
| Hgtot | 22.8 ± 4.6 | 33.5 ± 4.4 | 23.3 ± 2.1 | 25.5 ± 2.1 |
Note: Group A, untreated; Group B, LC sheet containing 5.0 × 105 cells alone; Group C, SY sheet containing 5.0 × 105 cells alone; and Group D, SY sheet plus LC sheet, each containing 5.0 × 105 cells. LC: layered chondrocyte; SY: synoviocyte. For each group, n = 6. ICRS: International Cartilage Regeneration and Joint Preservation Society; Ti: tissue morphology; Matx: matrix staining; Stru: structural integrity; Clus: cluster formation; Tide: tidemark opening; Bform: bone formation; SurfH: histological appraisal of surface architecture; FilH: histological appraisal of the degree of defect filling; Latl: lateral integration of defect‐filling tissue; Basl: basal integration of defect‐filling tissue; InfH: histological signs of inflammation. The total score (Hgtot) range is 11–45.