TABLE 4.
Meta‐analysis of reported achondroplasia birth prevalence stratified by study setting and by region
| Pooled birth prevalence per 100,000 | Higgins I 2 test (95% CI) | ||||
|---|---|---|---|---|---|
| Quality effects model (95% CI) | Random effects model (95% CI) | p value b | N studies; N estimates | Quality index a | |
| Worldwide | 4.6 (3.9–5.4) | 4.5 (4.1–5.0) |
84.3 (81.3–86.9) <.001 |
52; 90 | 23.0 |
| Specialized care c | 13.3 (5.3–24.6) | 16.4 (8.8–26.3) |
78.4 (64.3–87.0) <.001 |
14; 14 | 30.2 |
| Other settings d | 4.2 (3.5–4.9) | 4.2 (3.7–4.6) |
84.2 (80.8–87.0) <.001 |
38; 76 | 18.8 |
| North America | 4.2 (3.5–5.0) | 4.2 (3.5–4.9) |
71.18 (51.3–82.9) <.001 |
9; 15 | 52.5 |
| South America | 3.5 (2.1–5.3) | 3.9 (2.5–5.7) |
91.4 (84.1–95.4) <.001 |
5; 6 | 11.0 |
| Europe | 3.5 (3.0–4.2) | 3.6 (3.2–4.0) |
76.2 (67.9–82.4) <.001 |
13; 40 | 14.5 |
| North Africa and Middle east | 35.1 (14.9–63.0) | 43.1 (23.0–69.3) |
82.6 (71.5–89.4) <.001 |
13; 13 | 18.6 |
| Sub‐Saharan Africa | 17.9 (3.0–42.8) | 12.8 (2.2–30.6) |
82.7 (60.5–92.5) <.001 |
5; 5 | 65.4 |
| South and Southeast Asia/Oceania | 5.9 (2.9–10.0) | 6.3 (3.8–9.4) |
61.9 (26.7–80.3) <.001 |
11;11 | 33.1 |
Abbreviation: CI, confidence intervals.
a
The quality index represents the extent to which (percent) the weights of the inverse variance fixed effect model are redistributed by the application of the quality effect weights.
b
Chi2 p‐value.
c
Women who gave birth in a specialized care setting (i.e., referral center or tertiary hospital).
d
Women who gave birth in other settings (not a referral center or tertiary hospital).