TABLE 4.

Electrophysiological voltage‐clamp measurements of acutely isolated CD11b⁺ microglia from ischemic MCAO mouse brain

Gender			P2X4		Kir2.1		Kv1.3
		Capacitance (pF)	Current (pA)	Density (pA/pF)	Current (pA)	Density (pA/pF)	Current (pA)	Density (pA/pF)
Male	Ipsilateral	6.77 ± 3.19 (n = 77)	48.00 ± 60.67 (n = 26)	5.03 ± 6.02 (n = 26)	82.53 ± 97.18 (n = 77)	10.92 ± 11.13 (n = 77)	14.61 ± 21.71 (n = 77)	2.56 ± 4.56 (n = 77)
	Contralateral	3.00 ± 1.86 (n = 42) *p < 5 × 10−10	4.28 ± 4.26 (n = 21) *p < 5 × 10−3	1.98 ± 246 (n = 21) *p < 5 × 10−2	5.83 ± 14.8 (n = 42) *p < 5 × 10−9	2.43 ± 6.09 (n = 42) *p < 5 × 10−7	0.12 ± 0.77 (n = 42) *p < 5 × 10−7	0.05 ± 0.30 (n = 42) *p < 1 × 10−5
Female	Ipsilateral	6.11 ± 3.41 (n = 82)	13.95 ± 20.70 (n = 44) # p < 2 × 10−5	2.02 ± 3.47 (n = 44) # p < 5 × 10−2	94.82 ± 114.47 (n = 82)	14.26 ± 14.19 (n = 82)	11.54 ± 34.15 (n = 81)	1.98 ± 4.90 (n = 81)
	Contralateral	3.13 ± 1.88 (n = 34) *p < 1 × 10−5	1.04 ± 1.94 (n = 24) *p < 5 × 10−4	0.33 ± 0.63 (n = 24) *p < 2 × 10−3	0.29 ± 1.71 (n = 34) *p < 1 × 10−10	0.14 ± 0.86 (n = 34) *p < 5 × 10−13	0.00 ± 0.00 (n = 34) * p < 5 × 10−3	0.00 ± 0.00 (n = 34) *p < 5 × 10−4

Note: “n,” combined number of individual cells from three or more animals. All data represented as mean ± SD; statistical significance determined by one‐way ANOVA followed by Tukey–Cramer's post hoc (alpha = 0.05). “*” versus ipsilateral microglia. “^#” versus male microglia.

Abbreviations: ANOVA, analysis of variance; MCAO, middle cerebral artery occlusion.