TABLE 4.
Gender | P2X4 | Kir2.1 | Kv1.3 | |||||
---|---|---|---|---|---|---|---|---|
Capacitance (pF) | Current (pA) | Density (pA/pF) | Current (pA) | Density (pA/pF) | Current (pA) | Density (pA/pF) | ||
Male | Ipsilateral | 6.77 ± 3.19 (n = 77) | 48.00 ± 60.67 (n = 26) | 5.03 ± 6.02 (n = 26) | 82.53 ± 97.18 (n = 77) | 10.92 ± 11.13 (n = 77) | 14.61 ± 21.71 (n = 77) | 2.56 ± 4.56 (n = 77) |
Contralateral |
3.00 ± 1.86 (n = 42) *p < 5 × 10−10 |
4.28 ± 4.26 (n = 21) *p < 5 × 10−3 |
1.98 ± 246 (n = 21) *p < 5 × 10−2 |
5.83 ± 14.8 (n = 42) *p < 5 × 10−9 |
2.43 ± 6.09 (n = 42) *p < 5 × 10−7 |
0.12 ± 0.77 (n = 42) *p < 5 × 10−7 |
0.05 ± 0.30 (n = 42) *p < 1 × 10−5 |
|
Female | Ipsilateral | 6.11 ± 3.41 (n = 82) |
13.95 ± 20.70 (n = 44) # p < 2 × 10−5 |
2.02 ± 3.47 (n = 44) # p < 5 × 10−2 |
94.82 ± 114.47 (n = 82) | 14.26 ± 14.19 (n = 82) | 11.54 ± 34.15 (n = 81) | 1.98 ± 4.90 (n = 81) |
Contralateral |
3.13 ± 1.88 (n = 34) *p < 1 × 10−5 |
1.04 ± 1.94 (n = 24) *p < 5 × 10−4 |
0.33 ± 0.63 (n = 24) *p < 2 × 10−3 |
0.29 ± 1.71 (n = 34) *p < 1 × 10−10 |
0.14 ± 0.86 (n = 34) *p < 5 × 10−13 |
0.00 ± 0.00 (n = 34) * p < 5 × 10−3 |
0.00 ± 0.00 (n = 34) *p < 5 × 10−4 |
Note: “n,” combined number of individual cells from three or more animals. All data represented as mean ± SD; statistical significance determined by one‐way ANOVA followed by Tukey–Cramer's post hoc (alpha = 0.05). “*” versus ipsilateral microglia. “#” versus male microglia.
Abbreviations: ANOVA, analysis of variance; MCAO, middle cerebral artery occlusion.