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Molecular basis for the interaction of compounds 9LI and benzimidazole into SOS1-binding pocket of KRASG12D mutant. (A) The superimposed structure of compounds 9LI and benzimidazole are shown in stick and KRAS mutant in surface model. (B) Spatial arrangements of the residues involved in binding of compounds 9LI and benzimidazole with binding pocket. The models were generated using PyMOL (DeLano Scientific, LLC). 9LI, 4,6-dichloro-2-methyl-3-aminoethyl-indole.
