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Molecular basis for the interaction of compounds 1a, 2d, and 3a into SOS1-binding pocket of iKRASG12D. (A) The superimposed structure of compounds 1a, 2d, and 3a are shown in stick and iKRAS in surface model. (B) Spatial arrangements of the residues involved in binding of compounds 1a, 2d, and 3a with binding pocket. The models were generated using PyMOL (DeLano Scientific, LLC).
